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Examine demonstrates superior biocompatibility and mechanical efficiency of the Plielle™ urethral help system.
— Professor Chris Chapple, MD, co-inventor and chief in useful urology
FT. WAYNE, IN, UNITED STATES, January 9, 2026 /EINPresswire.com/ — Audaxis Medical, a ladies’s well being firm pioneering next-generation, tissue-inspired options for stress urinary incontinence (SUI), at present introduced peer-reviewed outcomes from its preclinical research to be revealed in the Could 2026 problem of Biomaterials, one of many world’s main journals in supplies science and biomedical engineering.
SUI is a continual and infrequently debilitating situation in which on daily basis bodily actions—reminiscent of coughing, laughing, or train—trigger involuntary urine leakage on account of weakened pelvic help. One in three ladies globally (and greater than 30 million ladies in the U.S. and Europe) expertise SUI, and plenty of stay untreated on account of considerations surrounding conventional mesh implants. By emulating pure pelvic help tissue and demonstrating a good biocompatibility profile, Plielle is designed to revive confidence in surgical intervention and increase entry to definitive therapy choices.
The revealed research evaluated the Plielle™ urethral help system—Audaxis Medical’s proprietary polyurethane scaffold engineered to reflect the compliance, resilience, and transforming habits of pure pelvic help tissue. Utilizing a validated SUI mannequin, the analysis demonstrated superior tissue integration, a lowered pro-inflammatory response, and preservation of mechanical properties following implantation. Materials and bench testing additional confirmed structural stability below dynamic physiological hundreds, with no proof of oxidative degradation, distinguishing Plielle from the well-documented deterioration patterns related to polypropylene mesh.
“This research represents a serious step towards delivering a next-generation implant that displays how the physique’s personal fascial tissues behave,” stated Professor Chris Chapple, MD, co-inventor and internationally acknowledged chief in useful urology. “For many years we’ve relied on supplies that didn’t match the biology. This analysis suggests Plielle strikes us nearer to a assemble that genuinely aligns with native help tissue operate.”
“The polyurethane scaffold reveals a stage of tissue integration and organic compatibility we merely don’t see with polypropylene,” added Professor Sheila MacNeil, PhD, co-inventor and main professional in biomaterials and tissue engineering. “These information spotlight the significance of designing implants that rework harmoniously with the host surroundings moderately than provoke continual inflammatory responses.”
About Audaxis Medical
Audaxis Medical is a ladies’s well being firm pioneering next-generation, biomaterial options for pelvic ground issues. Its flagship platform, the Plielle™ urethral help system, is constructed on a proprietary polyurethane scaffold engineered to imitate the mechanical and organic habits of pure pelvic tissue. Audaxis is dedicated to bettering security, sturdiness, and affected person outcomes for the hundreds of thousands of girls affected by stress urinary incontinence.
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